Manor Preboards Module 5 Practice Test

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• The most commonly used diluent in powders for capsules
• Which granulation process involves melting solids and reducing them to beads or powder by spraying the molten feed into a stream of air or other gas?
• Absorbed Film and Interfacial Tension Theory describes the role of a film at the interface in stabilizing emulsions. Which statement best reflects this theory?
• To prevent logo infilling, which statements are correct?
• What is pharmacovigilance and why is it important?
• In preventing logo bridging, how many of the following statements are correct?
• Which of the following statements about liniments is correct?
• Which statement best describes warfarin's mechanism of action?
• Which statement best describes the major safety differences between SSRIs and TCAs as antidepressants?
• How do NSAIDs affect renal perfusion and prostaglandin synthesis?
• Which size reduction law states that the work used to reduce the particle size is proportional to the square root of diameter of particle produced?
• The system consisting of a drug core and an osmotically active substance surrounded by a semipermeable membrane with a laser-drilled orifice for drug exit is called:
• What is the role of P-glycoprotein in pharmacology?
• In dry granulation, what term describes the large compressed particles produced before milling?
• What is heparin's mechanism of action and how is its effect monitored?
• Which statement correctly describes the mechanism of proton pump inhibitors?
• D&C Red 28 is most closely associated with which pigment name?
• Differentiate between adverse drug reaction and side effect.
• Partial spray drying within the logo causes which defect?
• Which statement best describes the mechanism of action of angiotensin II receptor blockers (ARBs)?
• Which method is specifically cited as a variation of the dry gum method for emulsions containing volatile oils?
• In preventing tablet core erosion, how many of the following statements are correct?
• During a rabies outbreak, a vaccine manufacturer stops selling its product without informing the FDA. Which law is violated?
• To change the final tablet silhouette, which part would you adjust?
• Which cytochrome P450 isoenzyme metabolizes warfarin most significantly?
• Which tablet type is described as a dry coated tablet with two parts: an internal core and surrounding coat?
• Which granulation process involves the formation of spherical particles from wet granulation?
• Which part is responsible for pressing the powder into the die cavity to form a tablet?
• Which statement best describes the role of alpha-adrenergic antagonists in treating hypertension and benign prostatic hyperplasia, with doxazosin as an example?
• The constant 111.11 in the equations for the second method represents which quantity?
• What is a common adverse effect of long-term corticosteroid use?
• Suppositories have advantages EXCEPT which statement?
• FD&C Red 3 is associated with which colorant?
• Metformin, when used as monotherapy in type 2 diabetes, is unlikely to cause hypoglycemia.
• Which coating provides delayed release by resisting gastric fluid and dissolving in the intestine?
• Which coating type is primarily used to mask tastes and odors and improve stability by layering sugar?
• FD&C Red 40 colorant is which option in the following list?
• Rifampin commonly interacts with oral contraceptives by causing what effect?
• Catapres® patch is an example of which transdermal patch type?
• Which diuretic class inhibits NaCl reabsorption in the distal tubule?
• Part of a tableting machine which compresses the powder/granules for tableting into the die cavity to form the desired tablet.
• The following steps may be done during manufacturing in order to prevent Film Cracking (Type 2): I. Improve drying (reduce spray rate or increase temperatures) to offset overwetting. II. Increase pan speed to minimize dwell time in spray zone. III. Use high solids coating systems to reduce moisture burden on drying process. IV. Reduce processing temperatures to minimize core thermal expansion.
• Why is rifampin a potent inducer of liver enzymes and what is a common drug interaction?
• In adhesive-type transdermal DDS, how many of the following statements are correct?
• Excessive use of binders can affect which tablet properties?
• A near saturated solution of sucrose in water is called:
• Glucocorticoids affect glucose metabolism and immune function. Which best describes their effect?
• Which size reduction law states that the size reduction is directly proportional to the new surface formed?
• The following steps may be done during manufacturing in order to prevent logo infilling: I. Minimize foam generation during preparation of coating suspension. II. Reduce atomizing conditions and/or reduce drying conditions to minimize risk of spray drying. III. Improve drying (reduce spray rate or increase temperatures) to offset overwetting. IV. Increase pan speed to minimize dwell time in spray zone.
• Which statement correctly distinguishes bactericidal from bacteriostatic antibiotics?
• In reservoir-type transdermal DDS, how many of the following statements are correct?
• Extraction by macerating crude drug in gentle heat is called which?
• In preventing tablet breakage, how many of the following statements are correct?
• Which antibiotic is commonly considered bacteriostatic?
• Which granulation method forms a wet mass by adding a binder and then dries after sieving?
• This defect is a result of partial spray drying or overwetting.
• Which component directly performs the compression of powder within the tableting assembly?
• What is the effect of aspirin on platelets and its clinical use?
• How do monoclonal antibodies work as therapeutics and give an example?
• Which granulation method is characterized by creating a cohesive mass that is then blended and dried after passing through sieves?
• Which statement about reservoir-type transdermal patches is true?
• Determining Isotonicity Value involves several statements about hemolytic testing and freezing point methods. Which option is correct?
• Liniments may be liquid or semi-solid in nature. Which statement best reflects this?
• Which class is an example of time-dependent antibiotics?
• Which statement best describes Sodium Chloride Equivalent (E) in isotonicity calculations?
• How does insulin differ from oral hypoglycemic agents in mechanism?
• Which statement correctly describes the location of the drug in a reservoir-type patch?
• Which term describes a near-saturated sugar solution in water used in pharmaceutical formulations?
• In a patient with peptic ulcer disease, which analgesic is generally preferred and why?
• Red man syndrome is most commonly associated with which antibiotic, particularly with rapid intravenous infusion?
• In a case where a patient purchases maintenance drugs with a prescription, booklet, and ID, which law is being violated?
• Part of a tableting machine which guides the movement of tableting punches.
• Which antibiotic is bactericidal?
• Clonidine patch can be applied to the following skin sites: select the classification.
• Class I Methods: Which statement is correct regarding isotonicity adjustment methods?
• Which statement about liposomes is NOT true?
• Which statement best defines an adverse drug reaction?
• If roughness is caused by partial spray drying, which adjustment helps minimize this effect?
• Regarding mechanical mixers for emulsions, which statement is most accurate?
• The following are examples of machines used in large-scale mixing in Wet Granulation EXCEPT:
• Duragesic® is an example of which transdermal patch type?
• In beta-blocker overdose, which of the following best describes the typical clinical picture and a standard component of its management?
• The following types of lactose has the disadvantage of undergoing Maillard reaction of reaction with amine drugs and alkaline lubricants, EXCEPT:
• Regarding percutaneous absorption of drugs from transdermal patches, which of the following statements are true?
• Name two common adverse effects of loop diuretics.
• What is the first-line drug for the management of anaphylaxis?
• Which tablet form consists of an internal core surrounded by a coating in a dry coating process?
• Clonidine (Catapres-TTS) transdermal drug delivery system can be applied to the following skin site:
• Which statement about Class II Methods is correct?
• Testosterone (Androderm) transdermal drug delivery system can be applied to the following skin site:
• Which system is also known as a monolith, where the drug is homogeneously dispersed in a rate-controlling medium?
• What is the difference between short-acting and long-acting inhaled beta-agonists in asthma therapy?
• Which method is an example of Class II isotonicity adjustment?
• Spans and Tweens are considered:
• Running powder consists of:
• The component that stores feed material before compression is called which?
• Long-term use of proton pump inhibitors has been associated with which risk?
• Which coating results in a thin polymer film forming a skin-like layer on the tablet surface?
• Coalescence of oil globules in an oil-in-water emulsion is called?
• Ostwald ripening destabilizes particle growth due to fluctuations in which storage parameter(s)?
• FD&C Red 3 is associated with which colorant?
• In percolation for syrups, the percolator design near the lower orifice should be which shape?
• Explain the concept of drug half-life and its relevance to steady-state dosing.
• Describe the mechanism of action of proton pump inhibitors.
• Name a drug that can cause serotonin syndrome when combined with SSRIs and explain its mechanism.
• In suspected MRSA infection, what is the general approach to antibiotic choice?
• The following steps may be done during manufacturing in order to prevent delayed dissolution for immediate release products: I. Adjust process conditions to facilitate reduction in processing temperatures. II. Use high solids system to enable use of low processing temperature. III. Improve drying (reduce spray rate or increase temperatures) to offset overwetting. IV. Increase pan speed to minimize dwell time in spray zone
• What Liso value is used for uni-univalent electrolytes in isotonicity calculations?
• A common side effect of ACE inhibitors and how is it managed?
• Name an anti-seizure drug that induces cytochrome P450 and has teratogenic risk.
• Core swelling due to excessive moisture uptake during coating application leads to which defect?
• In matrix-type transdermal DDS, how many of the following statements are correct?
• In isotonicity, which statement about Class I and Class II adjustment methods is correct?
• Which excipient is not typically used to impart compression characteristics to tablet formulation?
• Which coating is applied as a concentrated sugar solution to improve compliance and mask tastes and odors?
• In which scenario is NSAID-induced reduction in renal perfusion least likely to occur?
• Testosterone patch can be applied to the following skin sites: select the classification.
• In preventing tablet twinning, how many of the following statements are correct?
• Which component acts as the receptacle for granules before they are pressed?
• Which statement best describes the primary use of liniments?
• A pharmacist dispenses Valium to a customer who forgot her prescription. Which law is violated?
• What is the action of a competitive antagonist at a receptor, and how can its effect be overcome? Example: flumazenil.
• What is the mechanism of action of ACE inhibitors?
• Which component governs the motion path of the punches?
• D&C Red 28 is which colorant?
• The term 'impalpable' refer to a substance that is
• Which statement about liposomes is NOT true?
• Which statement best describes the effect of broad-spectrum antibiotics on resistance risk?
• Which combination of sealing methods is used to seal ampoules?
• What is the therapeutic use of acetaminophen and its major risk at high doses?
• Which organ is most directly influenced by P-glycoprotein activity in drug absorption and distribution?
• Which statement accurately describes how monoclonal antibodies function as therapies, with rituximab as an example?
• Which antibiotic class is commonly associated with nephrotoxicity and ototoxicity?
• Which method is an example of Class I isotonicity adjustment?
• What is the mechanism of action of metformin in type 2 diabetes?
• Why are non-selective beta-blockers contraindicated in severe asthma?
• This defect is associated with exposure of tablet cores to coating process conditions rather than the coating itself.
• The following steps may be done during manufacturing in order to prevent rough coatings: I. If roughness is caused by partial spray drying, reduce atomizing conditions and/or reduce drying conditions to minimize this effect. II. Reduce coating solids if viscosity is too high for effective atomization. III. If roughness is caused by overwetting, improve drying conditions in the process. IV. Increase solids content to decrease viscosity.
• The following excipients impart satisfactory compression characteristics to tablet formulation except:
• Which statement best differentiates irreversible enzyme inhibitors from reversible inhibitors in pharmacology?
• Which process is an air-fluidized technique used to coat tablets and then granulate and dry them?
• Regarding Transdermal Delivery Systems, how many of the following statements are correct?
• In isotonicity calculations, which method uses the freezing point depression equation?
• What is the role of alpha-adrenergic antagonists in hypertension or benign prostatic hyperplasia?
• What is the mechanism of action of vancomycin and a major toxicity concern?
• Oriented Wedge Theory describes how emulsifying agents orient around droplets based on solubility. Which statement best reflects this theory?
• Surface Tension Theory explains how emulsifiers lower interfacial tension and promote droplet breakup. Which statement best reflects this theory?
• Which electrolyte disturbance is commonly associated with loop diuretics?
• What is the most common method for tableting active ingredients that are chemically incompatible?
• In preventing edge chipping, how many of the following statements are correct?
• Which method is a variation of the dry gum method for emulsions containing volatile oils?
• ACE inhibitors cough mechanism: The cough is primarily due to accumulation of which peptide?
• Which extraction method involves boiling in water for 15 minutes, cooling, straining, and making up to volume with water?
• Area whose air is filtered by a HEPA filter is considered to be what class of clean room?
• The Food and Drug Administration was formerly named the Bureau of Food and Drugs. Which law is cited?
• Methylphenidate (Daytrana) transdermal drug delivery system can be applied to the following skin site:
• Which tablet coating is made from the hydrolysis product of collagen and helps with swallowing while preventing counterfeiting?
• Which component guides the punches during their movement in the compression cycle?
• If roughness is caused by overwetting, which adjustment helps?
• Which statement best describes a matrix-type patch?
• Sealing of ampoule is performed by which method(s)?
• Which statement about glass types is correct?
• Which granulation method is the cheapest and involves slugging followed by milling and screening?
• In Sprowl's method, the E value is fixed at what value?
• Which statement best describes the factors that influence drug distribution and the term that describes the volume in which a drug distributes?
• Minimum effective velocity of a HEPA filter is:
• Which antibiotic is a bacteriostatic protein synthesis inhibitor that binds the 50S ribosomal subunit?
• Which statement about first-pass metabolism is true?
• Nicotine (Nicoderm) transdermal drug delivery system can be applied to the following skin site:
• Capsules containing medicines (in the form of granules) coated with slow-dissolving materials to release at different times are called:
• How does atropine affect heart rate and its clinical use?
• Which granulation process uses a sufficient volume of hot air to evaporate and dry liquid droplets and can be used in encapsulation?
• Which granulation method uses an air suspension technique to coat and dry particles and granules?
• Bond's Law describes the relationship between work and particle diameter; it states that the work required is proportional to:
• Warfarin inhibits which enzyme as part of its anticoagulant effect?
• Which statement best describes the action of competitive antagonists at receptors?
• Film Cracking Type 1 in pharmaceutical film coating is caused by what factors?
• The equation for compaction is also known as which?
• Excessive use of binders affects which of the following tablet characteristics?
• In the White Vincent Method, the diluting vehicle must be isotonic.
• FD&C Red 40 is commonly known as which colorant?
• Part of a tableting machine which determines the shape and size of the tablet.
• Spansules are capsules containing medicines in granules coated to release drug at different times.
• Which statement about Class II methods is true?
• Which statement best describes the difference between time-dependent and concentration-dependent antibiotics?
• Part of a tableting machine in which granules for compression are stored.
• The component that sets tablet dimensions by defining the cavity used in compression is which?
• FD&C Yellow 6 is also known commercially as which color?
• The following steps may be done during manufacturing in order to prevent Film Cracking (Type 1): I. Reduce processing temperatures to minimize core thermal expansion. II. Reduce drying conditions (or increase spray rate) so that some moisture retention in the coating occurs due to augment plasticization effects (thus increasing film flexibility) III. Improve drying (reduce spray rate or increase temperatures) to offset overwetting. IV. Increase pan speed to minimize dwell time in spray zone.
• Which statement about liposomes is NOT true?
• Percolation is a method of preparing syrups which involves passing distilled water or medicated component slowly through a bed of sucrose. Which of the following are correct?
• What is boric oxide responsible for in Type II glass?
• Methylphenidate patch can be applied to the following skin sites: select the classification.
• A provincial hospital director announces a policy to reduce the hiring of female employees. Which law is implicated?
• In selecting the ointment base, which factor is NOT typically considered?
• How do thiazide diuretics help treat hypertension, and what is a common electrolyte disturbance?
• D&C Yellow 10 is a color additive that corresponds to which color?
• Which adverse effect is most commonly associated with aminoglycosides?
• Extraction by macerating crude drug in either cold or hot water for a short period of time is called which?
• HEPA filters are used for filtration of which medium?
• Which component is primarily involved in confinement and shaping of the tablet during compression?
• Electric Double Layer Theory describes the charge arrangement around an emulsion droplet and its impact on stability. Which statement best reflects this theory?
• Scopolamine (Transderm Scop) transdermal drug delivery system can be applied to the following skin site:
• For MRSA pneumonia, which agent is commonly preferred due to excellent lung penetration and safety profile?
• What is the mechanism of loop diuretics and their clinical use in heart failure?
• The component that stores feed material before compression is called which?
• Scopolamine patch can be applied to the following skin sites: select the classification of these sites.
• Which statement best differentiates potency from efficacy?
• What is the primary action of statins and a major adverse effect to monitor?
• Which best describes the mechanism of action of proton pump inhibitors and a common adverse effect?
• Which action reduces moisture burden on the drying process during coating?
• Which adverse outcome is a known risk of aspirin use due to COX-1 inhibition?
• Which action specifically helps minimize dwell time in the spray zone when preventing Film Cracking Type 2?
• Which statement best describes the mechanism of action of aminoglycosides and a key toxicity?
• What is the therapeutic serum range for digoxin and what monitoring parameter guides dosing?
• How does calcitriol affect calcium homeostasis?
• What is the mechanism of action of beta-lactam antibiotics?
• FD&C Yellow 6 is associated with which colorant?
• What is first-pass metabolism and its clinical consequence for oral drugs?
• Which of the following is a major adverse effect to monitor with statin therapy?
• Which component holds granules prior to compression?
• cGMP stands for which of the following?
• Which extraction method involves exposing solid ingredients to a prescribed solvent for about three days with frequent agitation?
• Which size reduction law states that the work required to reduce the size of a given quantity of material is constant for the same reduction ratio regardless of initial size?