Ace Manor Preboards Module 5 in 2026 – Your Ultimate Power-Up Practice!

Excessive binder makes tablets too cohesive, increasing hardness and reducing porosity, which slows water entry and the tablet’s breakup. That directly impedes disintegration—the first step in releasing the drug. If the tablet disintegrates more slowly, dissolution—the drug entering solution—also slows, especially for poorly soluble drugs. Since bioavailability depends on how much drug actually dissolves and is absorbed, slower dissolution can lower bioavailability. So, too much binder can affect disintegration, dissolution, and ultimately bioavailability, making all of the above the best answer.