Which statement about liposomes is NOT true?

Which statement about liposomes is NOT true?

• A. Liposome encapsulated drugs are less susceptible to degradation.
• B. Liposomes can encapsulate only water soluble drugs.
• C. Liposomes can encapsulate water soluble and lipid soluble drugs.
• D. Liposomes can decrease a drug's toxicity.

Answer: (C)

Liposomes can carry both water-soluble and lipid-soluble drugs. Their structure has a hydrophilic interior where water-soluble (hydrophilic) drugs reside, and a phospholipid bilayer that can incorporate lipid-soluble (hydrophobic) drugs within the membrane. So the statement that they can encapsulate only water-soluble drugs isn’t accurate. In addition, liposomes protect encapsulated drugs from degradation, helping them stay intact longer in the body, and they can reduce a drug’s toxicity by altering distribution and limiting exposure to non-target tissues.

Liposomes can carry both water-soluble and lipid-soluble drugs. Their structure has a hydrophilic interior where water-soluble (hydrophilic) drugs reside, and a phospholipid bilayer that can incorporate lipid-soluble (hydrophobic) drugs within the membrane. So the statement that they can encapsulate only water-soluble drugs isn’t accurate. In addition, liposomes protect encapsulated drugs from degradation, helping them stay intact longer in the body, and they can reduce a drug’s toxicity by altering distribution and limiting exposure to non-target tissues.